Yes, but it will take work. Remove the Bio-wheel from 330 filter. Place about 2 inches of live sand, and some live rock. Only about two fishes, a couple snails and hermits, change about 2-3 gallons of water every two weeks. A good protein skimmer won't fit on that tank. You could run a Bak Pak 2 skimmer also instead of 330 biowheel. Place come carbon in the filter at least. Fish only tank not specific on lighting. IMO, get bigger tank for saltwater. Use 10 gallon tank as a sump for larger tank. 8)
