Hmm, a year and a half ago i bought a single pregnant guppy, and since then I've had several generations come out just out of that one litter. So a year and a half's worth of inbreeding. And I personally can't say i like the results down the line. They're still born healthy and grow and live fine and everything. But they all look the same, all the males and yellow snakeskins and the females are dull yellow. But what I've noticed in terms of the males I'm getting - its very rare for me to get any males and when I do get them they tend to stay small and their tails are not very impressive. When I say rarely get males and that they stay small, i mean compared to regular guppy litters - males are even less common, and stay much smaller than males I see in the store for example. Haven't seen any deformities, but still. So i personally reccomend that you do throw in some fresh blood once in a while.