To awnser your question, yes, you could go with two cannisters, provided they were large enough. I'd use at least two FX5's or Eheim's equavilent.
BUT, like everyone else has said, if you're ready to go to that much trouble, why not just go with a sump? it would be both cheaper and easier than multiple cannisters. You don't need to buy a prebuilt sump either; another fishtank, or even a rubbermaid container will do nicely.