Other conditioners ADD a slime coat while Prime promotes it naturally happening.
Fish naturally replace/renew their slime coats constantly. It's kind of like using artificial tears in your eyes... your eyes already produce tears to keep them moist, and unless you have a medical condition, why would you use them?
Prime has the added benefit of an ammonia/nitrite detoxifier, but you shouldn't need that in a fully cycled tank, or you have chloramines in your tapwater.